Answer. As long as you need to take them. patients will generally stay on the medications for 6-12 months *after* resolution of depression symptoms. I started taking Wellbutrin for depression, and just go prescribed Trazodone as well. I was wondering if anyone has taken the two and noticed a big difference. Summary. Drug interactions are reported among people who take Trazodone hydrochloride and Wellbutrin together. This study is created by eHealthMe based on reports of 444 people who take Trazodone hydrochloride and Wellbutrin from FDA, and is updated regularly. An overdose of Trazodone in combination with other drugs can be fatal. Symptoms of a Trazodone overdose may include: Breathing failure, drowsiness, irregular heartbeat, prolonged, painful erection, seizures, vomiting. If you suspect an overdose, seek medical attention immediately. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Gelin on can i take trazadone with wellbutrin: These medicines are both from the same drug family. Please talk with the doctor who is prescribing this medicine to you. As long as the medications are closely followed by the doctor, then the risk of having a bad drug. Relist: Answer quality. She completely ignored the symptoms I am having since Wellbutrin was added to my regimen. Another person also provided an answer that indicated that the combination of drugs that I am on is dangerous, and explained how this particular combination of Wellbutrin, Zoloft and Trazodone can result in increased blood levels of. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Compare Trazodone vs. Wellbutrin, which is better for uses like: Depression, Anxiety and Major Depression. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Wellbutrin 3.4/5 over Trazodone 3.3/5 in overall satisfaction. You can theoretically take Xanax and trazodone together, but you might experience heightened side effects of one or both. For example, you might experience confusion, dizziness, and coordination and concentration problems if you take Xanax and trazodone together.